The Human Frontier Science Program has funded a three-year project to study post-synaptic structure and function. The structure and function of the pre-synapse is relatively well-understood. However, while the post-synapse is critical to a range of brain disorders, the complex structure attached to the post-synaptic membrane—known as the post-synaptic density—remains largely mysterious.
This ambitious project aims to understand the dynamic organization of the post-synaptic scaffold, using a range of methods including: genomics, transcriptomics, proximity labeling, mass spectrometry, Drosophila neurogenetics, protein modeling, X-ray crystallography, cryo-electron microscopy, and electron tomography.
In Singapore, the Claridge-Chang Lab is looking for a postdoctoral fellow with a strong background in molecular neuroscience to join this project. The collaborative project will involve interactions with a number of other groups, including the Copley, Hoelz, Manser, and Robinson labs.
To apply, send a CV to the Claridge-Chang Lab.