Postdoctoral positions are available to examine brain circuitry in normal and dementia-model mice. Experiments will use either: (1) optogenetic circuit mapping technology in brain slices to identify brain circuitry; (2) behavioural assays, in combination with in vivo optogenetics, to determine the behavioural roles of these circuits; and (3) determine the cellular, synaptic and molecular mechanisms underlying circuit defects associated with dementia.
These positions are offered as part of a 5-year, multi-institutional program in the dynamic neuroscience research environment of Singapore. Participating laboratories include:
G.J. Augustine – optogenetic mapping of cerebellar circuits. (email: George.augustine@ntu.edu.sg)
Chen –circuits in deep cerebellar nuclei (albert.chen@ntu.edu.sg)
T.H. Ch’ng – molecular changes in nuclear signaling associated with dementia. (thchng@ntu.edu.sg)
Dawe – incorporation of newborn neurons into hippocampal circuits. (gavin_dawe@nuhs.edu.sg)
Goh – neurogenesis defects underlying hippocampal circuit dysfunction. (eyleen.goh@duke-nus.edu.sg)
Kandiah – neuroimaging and fluid biomarker research in Alzheimer’s disease and vascular dementia (nagaendran.kandiah@singhealth.com.sg)
Khanna – septo-hippocampal circuits. (sanjay_khanna@nuhs.edu.sg)
Libedinsky – circuits in prefrontal cortex of macaques. (camilo@nus.edu.sg)
K.L. Lim – cellular/molecular mechanisms of dementia studied in patient-derived iPSCs. (kahleong.lim@duke-nus.edu.sg)
Makino – 2-photon, widefield imaging of cortical network activity in vivo. (hmakino@ntu.edu.sg)
Mitra – cellular mechanisms of stress and resilience. (RMitra@ntu.edu.sg)
Nizetic – dementia-related cellular defects in iPSC-derived neurons from human dementia patients. (d.nizetic@ntu.edu.sg)
J.C.G. Sng – epigenetics mechanisms underlying dementia-associated circuit defects. (phcsngj@nus.edu.sg)
Sreedharan – hippocampal long-term synaptic plasticity. (phssks@nus.edu.sg)
Tashiro – incorporation of newborn neurons into hippocampal circuits. (atashiro@ntu.edu.sg)
Vyas – Optogenetic control of memory-associated behaviors. (avyas@ntu.edu.sg)
S.-C. Yen – changes in neural coding and cortical circuitry associated with dementia. (shihcheng@nus.edu.sg)
Candidates should have a doctoral degree and experience in one or more of the following techniques: electrophysiology, optogenetics, in vivo imaging, iPSC technology, behavioural analysis and/or molecular biology, neuroimaging post-processing.
Please send curriculum vitae and names of three references to any of the PIs listed above or to the Program Director, George J. Augustine. While there is no formal application deadline, we are eager to have outstanding candidates join us as soon as possible.
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